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LYN-1604 dihydrochloride

CAS No. 2310109-38-5

LYN-1604 dihydrochloride( LYN-1604 2HCl（2216753-86-3 free basel) | )

Catalog No. M28580 CAS No. 2310109-38-5

LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LYN-1604 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
  • Description
    LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.(In Vitro):LYN-1604, to be the best candidate for a ULK1 agonist.?LYN-1604 induced cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.?LYN-1604 has potential for good therapeutic effects on TNBC by targeting ULK1-modulated cell death in vivo
  • In Vitro
    Cell Viability Assay Cell Line:MDA-MB-231 cells Concentration:0.5, 1.0 and 2.0 μM Incubation Time:Result:Induced cell death.Autophagy ratio was increased in a dose-dependent manner.Western Blot Analysis Cell Line:MDA-MB-231 cells Concentration:0, 0.5, 1, and 2 μM Incubation Time:24 hours Result:Induced remarkable up-regulation of Beclin-1 and degradation of p62, as well as transformation of LC3-I to LC3-II.
  • In Vivo
    Animal Model:24 female nude mice (BALB/c, 6-8 weeks, 20-22 g) Dosage:Low dose, 25 mg/kg; median dose, 50 mg/kg; high dose, 100 mg/kg Administration:Intragastric administration; once a day for 14 days Result:Significantly inhibited the growth of xenograft MDA-MB-231 cells. The body weights of mice were stable. By the end of the experiment, the liver and spleen weight indexes of mice were slightly increased in parts of the groups, while the kidney weight index was not affected in all dose groups.
  • Synonyms
    LYN-1604 2HCl（2216753-86-3 free basel) |
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2310109-38-5
  • Formula Weight
    657.54
  • Molecular Formula
    C33H45Cl4N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 50 mg/mL (76.04 mM)
  • SMILES
    [H]Cl.[H]Cl.ClC1=CC=C(C(OCC2=CC=C3C=CC=CC3=C2)CN4CCN(C(CN(CC(C)C)CC(C)C)=O)CC4)C(Cl)=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Liang WL, et al. Exploring the chemodiversity and biological activities of the secondary metabolites from the marine fungus Neosartorya pseudofischeri. Mar Drugs. 2014 Nov 24;12(11):5657-76.
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